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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4- triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4- triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents |
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الموضوع |
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كيمياء |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Fluorinated 1,2,4-triazoles 3 and benzenesulfonyl urea and thiourea derivatives as well as their cyclic sulfonylthioureas 4-10 were prepared as antimicrobial agents. The chemistry involves the condensation of sulfanilamide derivatives 1 with trifluoroacetic anhydride to give N-di(trifluoroacetyl) sulfonamides 2 which upon reaction with hydrazine hydrate afforded the corresponding triazole derivatives 3. Reaction of triazole derivative 3a with isocyanates and isothiocyanates gave the corresponding ureas 4 and thioureas 5. Cyclization of thiourea derivatives with ethyl bromoacetate, 1,2-diiodoethane, diethyl oxalate and α-bromoacetophenone derivatives yielded the corresponding 4-oxothiazolidines 7, thiazolidines 8, 4,5-dioxothiazolidines 9 and thiazolines 10. Preliminary biological screening of the prepared compounds revealed significant antimicrobial and mild antidiabetic activities. |
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ردمد |
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0022-1139 |
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اسم الدورية |
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Journal of Fluorine Chemistry |
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المجلد |
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132 |
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العدد |
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11 |
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سنة النشر |
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1432 هـ
2011 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Thursday, February 16, 2012 |
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الباحثون
| حسن مصطفى فيض الله | Faidallah, Hassan Mostafa | باحث | دكتوراه | hfaidallahm@hotmail.com |
| خالد أحمد العمري | Alamry, Khalid Ahmad | باحث | دكتوراه | k_alamry@yahoo.com |
| عبدالله محمد عسيري | Asiri, Abdullah Mohamed | باحث | دكتوراه | aasiri2@kau.edu.sa |
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