Document Details

Document Type : Article In Journal 
Document Title :
Bioactive C 15 acetogenins from the red alga Laurencia obtusa
Bioactive C 15 acetogenins from the red alga Laurencia obtusa
 
Subject : Chemistry 
Document Language : English 
Abstract : The petroleum ether extract of the red alga Laurencia obtusa afforded three new C 15 acetogenins (cyclic ether enyne): (12Z)-cis-maneonene-D (1), (12E)-cis-maneonene-E (2), and (12Z)-trans-maneonene-C (3), along with one known cis-maneonene-A (4). Blood neutrophils were prepared, cultured, and incubated for 24, 48, and 72 h in medium with and without isolated compounds. Blood neutrophils were prepared, cultured, and incubated for 24, 48 and 72 h in medium with and without the isolated compounds. Both morphology and DNA fragmentation methods assessed the percentage of neutrophils apoptosis in each culture. In the present study, several observations have been made concerning the apoptosis-inducing or inhibiting effect of 1 and 2. Both compounds had no inhibition of apoptosis but apoptosis was enhanced significantly by aging. However, 1 stimulated apoptosis of normal only at the initial 24 h. After that there was no significant difference in apoptosis with or without compound 1, while 2 stimulated apoptosis at all the times. The apoptosis induced by these two compounds was demonstrated by DNA fragmentation assay and microscopic observation. These observations suggest that compounds 1 and 2 may be involved in regulation of programmed death in the initiation and propagation of inflammatory responses. 
ISSN : 0009-2363 
Journal Name : Chemical and Pharmaceutical Bulletin 
Volume : 60 
Issue Number : 2 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Saturday, March 3, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سيف الدين نصر عيادAyyad, Seif-Eldin NResearcherDoctoratesnayyad2@yahoo.com
خالد عمر الفوتيAl-Footy, Khalid OmarResearcherDoctoratekalfooti@kau.edu.sa
وليد محمد العارفAlarif, Walied MohamedResearcherDoctoratewelaref@kau.edu.sa
طارق رشاد سبحيSobahi, Tariq RashadResearcherDoctoratedrtariq_s@hotmail.com
سالم أحمد باسيفBasief, Salem AResearcherDoctoratesbasaif@yahoo.com
محمد صالح إبراهيم توفيق مكيMakki, Mohamed S. I. TResearcherDoctoratemmakki@kau.edu.sa
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa
أمين يحيى الحلوانيAl Halawani, Amani YahyaResearcherDoctorate 
Adel Farid BadriaBadria, Adel FaridResearcherDoctorate 
Farid Abd Al Raheem BadriaBadria, Farid Abd Al RaheemResearcherDoctorate 

Files

File NameTypeDescription
 32494.pdf pdfAbstract
 32596.pdf pdfErratum

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