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Document Type |
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Article In Journal |
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Document Title |
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Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma |
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Subject |
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Chemistry |
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Document Language |
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English |
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Abstract |
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Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis. |
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ISSN |
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0223-5234 |
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Journal Name |
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European Journal of Medicinal Chemistry |
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Volume |
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46 |
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Issue Number |
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1 |
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Publishing Year |
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1432 AH
2011 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, March 3, 2012 |
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Researchers
| سيف الدين نصر عياد | Ayyad, Seif-Eldin N | Researcher | Doctorate | snayyad2@yahoo.com |
| محمد صالح إبراهيم توفيق مكي | Makki, Mohamed S. I. T | Researcher | Doctorate | mmakki@kau.edu.sa |
| نزيهه سليمان الكيال | Al-Kayal, Nazeeha S | Researcher | Master | nalkayal@yahoo.com |
| سالم أحمد باسيف | Basief, Salem A | Researcher | Doctorate | sbasaif@yahoo.com |
| خالد عمر الفوتي | Al-Footy, Khalid Omar | Researcher | Doctorate | kalfooti@kau.edu.sa |
| عبدالله محمد عسيري | Asiri, Abdullah Mohamed | Researcher | Doctorate | aasiri2@kau.edu.sa |
| وليد محمد العارف | Alarif, Walied Mohamed | Researcher | Doctorate | welaref@kau.edu.sa |
| Farid Abd Al Raheem Badria | Badria, Farid Abd Al Raheem | Researcher | Doctorate | |
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